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Chinmedomics: A Powerful Approach Integrating Metabolomics with Serum Pharmacochemistry to Evaluate the Review

Ai-Hua Zhang, Hui Sun, Guang-Li Yan, Ying Han, Qi-Qi Zhao, Xi-Jun Wang

Engineering 2019, Volume 5, Issue 1,   Pages 60-68 doi: 10.1016/j.eng.2018.11.008

Abstract: the scientific elaboration of the efficacy of TCMs, and to further highlight the significant value of TCMChinese medicinal syndromes and formulae are two essential parts of TCM that directly relate to its efficacyThe serum pharmacochemistry of the TCM approach with metabolomics were integrated to establish an innovativechinmedomics strategy, which is able to explore syndrome biomarkers and evaluate TCM efficacy in orderChinese and Western medicine, and to provide a powerful approach to enhance the scientific value of TCM

Keywords： Chinmedomics     Serum pharmacochemistry of TCM     Efficacy     Metabolomics     Syndrome     Biomarkers     Quality markers    

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The Discussion of the Essence and Characters of the TCM, as well as the Formation and Devopment of theTCM Theory

Li Lianda,Jing Yuzhen

Strategic Study of CAE 2005, Volume 7, Issue 7,   Pages 24-26

Abstract:

This article discusses the essence and characters of the Traditional Chinese Medicine (TCM), as wellas the formation and devopment of the TCM theory.TCM in the modern times.TCM theory took its source at a great deal of practice which was a long time fight with disease.of the herb and medicine as well as the theory of the TCM.

Keywords： TCM     the modernization of the TCM     Yinyangwuxing     Tianrenheyi     Taijibagua    

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Translating the power of TCM into patients’ hope

Guangbiao Zhou,Zhu Chen

Frontiers of Medicine 2014, Volume 8, Issue 3,   Pages 265-267 doi: 10.1007/s11684-014-0329-z

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The Significant Strategic Status of Traditional Chinese Medicine (TCM) Should be Established

Jia Qian,Chen Yongjie,Chen Guangman,Yang Juping,Ying Guangrong

Strategic Study of CAE 2004, Volume 6, Issue 7,   Pages 4-13

Abstract:

Traditional Chinese Medicine(TCM) , based on the philosophic idea of “correlation between manFor thousands of years, TCM has made indelible contribution to the reproduction and prosperity of theIt is strongly suggested that five promotion projects, namely TCM policy and statute guarantee, TCM qualifiedpersonnel cultivation, TCM scientific research, development of TCM in rural areas and TCM administrativesystem reform, should be carried out in real earnest to make TCM develop in a sustainable way.

Keywords： traditional Chinese medicine (TCM)     TCM policy and statute guarantee     TCM qualified personnel     projectsof TCM in rural areas     TCM administrative system    

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Potential use of serum HBV RNA in antiviral therapy for chronic hepatitis B in the era of nucleos(t)ide

Fengmin Lu, Jie Wang, Xiangmei Chen, Dongping Xu, Ningshao Xia

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 502-508 doi: 10.1007/s11684-017-0590-z

Abstract: virus (HBV) are integrated into the life cycle of HBV replication, and the potential significance of serumThe production of HBV RNA virion-like particles should not be blocked by NA; in this regard, serum HBVTherefore, the concept of virological response is redefined as persistent loss of serum HBV DNA and HBVTherefore, the loss of serum HBV RNA would likely be a promising predicator for safe drug discontinuationThe clinical status of consistent loss of serum HBV RNA accompanied with low serum HBsAg levels might

Keywords： chronic hepatitis B     serum HBV RNA     nucleos(t)ide analogs     virological response     para-functional cure    

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TCM Views and Treatment on AIDS

Wang Wenkui

Strategic Study of CAE 2004, Volume 6, Issue 1,   Pages 44-47

Abstract:

Serious dysfunction of cell-mediated immune is the internal cause of AIDS infection, and the virus is the external cause. The external cause will work only by means of the dysfunction of cell-mediated immune. As all the conditions on which normal cell depends are created by the viscera (zang and fu) function, proper measures can be adopted to adjust the viscera function comprehensively, so the physical materials can be produced, then the essence and sprit emerged. Only with supporting from physical materials, essence and sprit, can the cell-mediated immune function be kept well to conquer and destroy the different kinds of virus, hence keeping physical and psychological well-being, strengthening the human immunity. So that the normal physiological activity can be maintained.

Keywords： TCM views and theatment     HIV/AIDS     immunity     viscera function    

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Effect of renal function and hemodialysis on the serum tumor markers in patients with chronic kidney

YU Xiaofang, XU Xialian, YE Zhibin

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 308-311 doi: 10.1007/s11684-007-0059-6

Abstract: with chronic renal failure, whether they have had hemodialysis or not, the specificity of some of the serumThe effects of renal function and hemodialysis were examined on serum levels of some of the tumor markersThere were no significant differences among the three groups in the serum concentrations of CA, AFP,of the corresponding tumors was decreased while serum AFP, CA, CA, PSA and fPSA were as valuable asHemodialysis further increased the serum level of CA and NSE.

Keywords： CKD     non-dialysis     valuable     detection     chronic    

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The Origin of Traditional Chinese Medicine and Thinking on Chinese Medicine Development

Wang Wenkui,Wang Feng,Wang Ling

Strategic Study of CAE 2006, Volume 8, Issue 4,   Pages 1-11

Abstract:

Although the TCM has developed a profound theory system and a fame of outstanding advantage in curativeeffect, it seems that the TCM is not quite adaptable to the development and requirement of the modem

A principle of “Adopting the advanced part of Western medicine to serve the TCM”First, TCM should strive for a consensus of TCM theory which focuses on the guiding principles of &ldquoBasides, TCM dose type should be ameliorated in order to meet the needs of society.

Keywords： traditional Chinese medicine (TCM)     development course & status of TCM     adopting the advanced part ofwestern medicine to serve the TCM     the dose type of traditional Chinese medicine    

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Direct acting antiviral-induced dynamic reduction of serum

Tung Huynh, Ke-Qin Hu

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 658-666 doi: 10.1007/s11684-019-0707-7

Abstract: Direct acting antiviral (DAA) treatments may reduce the elevated α fetoprotein (AFP), but data on how these treatments affect elevated AFP in patients with chronic hepatitis C (CHC) remain insufficient. In the present study, the frequency of baseline AFP elevations and their related factors, AFP dynamics during and after DAA treatment, and factors associated with AFP reduction was assessed. This retrospective study included 141 patients with CHC without hepatocellular carcinoma who received DAA and achieved sustained virological response. The details are as follows: mean post-treatment follow-up was 99 weeks (12–213); mean age, 57.8 years old; 52%, males; 79%, genotype (GT) 1; and 47%, cirrhosis. Pre-treatment AFP elevation (>5.5 ng/mL) was seen in 48.2% patients. On multivariate analysis, baseline AFP>5.5 was associated with the presence of cirrhosis ( =0.001), co-existing non-alcoholic steatohepatitis (NASH) ( = 0.035), and GT 1 ( = 0.029). AFP normalization was seen in 28.2% patients at treatment week 2, in 52% at the end of treatment, and in 73.4% at the end of follow-up. Post-treatment week 24 AFP normalization was associated with the absence of cirrhosis ( = 0.003), Child–Pugh score<6 ( = 0.015), and baseline AFP<10 ( = 0.015). AFP elevation is common in patients with CHC and independently associated with NASH, cirrhosis, and GT 1. DAA treatment resulted in AFP normalization as early as treatment week 2. Post-treatment week 24 AFP normalization is independently associated with the absence of cirrhosis, Child–Pugh score<6, and baseline AFP<10.

Keywords： chronic hepatitis C     α fetoprotein     direct acting antiviral treatment     cirrhosis    

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Proteomics study of Mycoplasma pneumoniae pneumonia reveals the Fc fragment of the IgG-binding protein as a serum

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 378-388 doi: 10.1007/s11684-021-0840-y

Abstract: Therefore, identifying serum biomarkers that indicate MPP progression and exploring new targeted drugsIn this study, serum samples were collected from patients with general MPP (GMPP) and SMPP to conduct

Keywords： severe Mycoplasma pneumoniae pneumonia     children     proteomics     Fc fragment of the IgG-binding protein     mechanistic target of rapamycin kinase inhibitor    

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The change of serum leptin and its relationship with platelet membrane glycoprotein Ib in patients with

XIA Dasheng, SONG Yanqiu, LI Chao, ZHANG Feng, WEI Minxin

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 352-355 doi: 10.1007/s11684-007-0067-6

Abstract: The aim of this paper was to investigate the change of serum leptin and its relationship with plateletSerum leptin was detected by enzyme linked immunosorbent assay.Multifactorial stepwise regression analysis showed that serum leptin in CHD patients was independentlyLogistic analysis demonstrated that serum leptin was independently correlated with the risk of CHD (serum leptin could affect blood platelet activation.
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Effect of electrokinetic property of charged polyether sulfone membrane on bovine serum albumin fouling

Xiaorong Meng, Shanshan Huo, Lei Wang, Xudong Wang, Yongtao Lv, Weiting Tang, Rui Miao, Danxi Huang

Frontiers of Environmental Science & Engineering 2017, Volume 11, Issue 2, doi: 10.1007/s11783-017-0907-9

Abstract: The effects of PES membrane interfacial electrokinetic property on the bovine serum albumin (BSA) membrane

Keywords： Charged PES UF membrane     BSA     Electrokinetic characterization     Adhesion force     Jump distance    

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Trends in serum lipid levels of healthy Chinese in Shanghai from 1973 to 1999

CHEN Haozhu, ZHOU Jun, CHEN Bin, ZHUANG Hanzhong, JIN Xuejuan, HAN Qingqing

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 5-10 doi: 10.1007/s11684-008-0002-5

Abstract: We assessed the secular trends in the serum lipid levels in Shanghai residents from 1973 to 1999.from four independent, cross-sectional, population-based surveys were used to analyze the trends in serumSerum lipid levels were measured in a single laboratory throughout the entire study period.A non-significant increase was noted from 1973–1974 to 1982–1983 in the serum lipid profiles; howeverSimilar trends were observed in the mean serum triglyceride (TG) and the mean serum low-density lipoprotein
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Downregulation effects of beta-elemene on the levels of plasma endotoxin, serum TNF-alpha, and hepatic

Jianguo LIU, Zhe ZHANG, Jiechang GAO, Jiwen XIE, Lin YANG, Shenjun HU

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 101-105 doi: 10.1007/s11684-011-0111-4

Abstract: The serum TNF-α level was detected using radioactive immunity.The results showed that β-elemene can downregulate the levels of plasma endotoxins, serum TNF-&alpha

Keywords： liver fibrosis     beta-elemene     endotoxin     CD14    

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Mechanism of hepatocellular damage in rat caused by low serum selenium

LU Yi, QU Bo, LIU Chang, YU Liang, Liu Xuemin, WANG Haohua, JIANG An, ZHANG Xiaogang

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 255-258 doi: 10.1007/s11684-008-0048-4

Abstract: The aim of this paper is to investigate the mechanism of hepatocellular damage in rats caused by low serumAt the end of the 12 week, the levels of serum selenium, glutathione peroxidase (GPX) and malondialdehydeThe levels of serum selenium and GPX in group A were markedly lower than those in group B.

Keywords： process     glutathione peroxidase     hepatocellular damage     group     Keshan Disease    

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Title Author Date Type Operation

Chinmedomics: A Powerful Approach Integrating Metabolomics with Serum Pharmacochemistry to Evaluate the

Ai-Hua Zhang, Hui Sun, Guang-Li Yan, Ying Han, Qi-Qi Zhao, Xi-Jun Wang

Journal Article

The Discussion of the Essence and Characters of the TCM, as well as the Formation and Devopment of theTCM Theory

Li Lianda,Jing Yuzhen

Journal Article

Translating the power of TCM into patients’ hope

Guangbiao Zhou,Zhu Chen

Journal Article

The Significant Strategic Status of Traditional Chinese Medicine (TCM) Should be Established

Jia Qian,Chen Yongjie,Chen Guangman,Yang Juping,Ying Guangrong

Journal Article

Potential use of serum HBV RNA in antiviral therapy for chronic hepatitis B in the era of nucleos(t)ide

Fengmin Lu, Jie Wang, Xiangmei Chen, Dongping Xu, Ningshao Xia

Journal Article

TCM Views and Treatment on AIDS

Wang Wenkui

Journal Article

Effect of renal function and hemodialysis on the serum tumor markers in patients with chronic kidney

YU Xiaofang, XU Xialian, YE Zhibin

Journal Article

The Origin of Traditional Chinese Medicine and Thinking on Chinese Medicine Development

Wang Wenkui,Wang Feng,Wang Ling

Journal Article

Direct acting antiviral-induced dynamic reduction of serum

Tung Huynh, Ke-Qin Hu

Journal Article

Proteomics study of Mycoplasma pneumoniae pneumonia reveals the Fc fragment of the IgG-binding protein as a serum

Journal Article

The change of serum leptin and its relationship with platelet membrane glycoprotein Ib in patients with

XIA Dasheng, SONG Yanqiu, LI Chao, ZHANG Feng, WEI Minxin

Journal Article

Effect of electrokinetic property of charged polyether sulfone membrane on bovine serum albumin fouling

Xiaorong Meng, Shanshan Huo, Lei Wang, Xudong Wang, Yongtao Lv, Weiting Tang, Rui Miao, Danxi Huang

Journal Article

Trends in serum lipid levels of healthy Chinese in Shanghai from 1973 to 1999

CHEN Haozhu, ZHOU Jun, CHEN Bin, ZHUANG Hanzhong, JIN Xuejuan, HAN Qingqing

Journal Article

Downregulation effects of beta-elemene on the levels of plasma endotoxin, serum TNF-alpha, and hepatic

Jianguo LIU, Zhe ZHANG, Jiechang GAO, Jiwen XIE, Lin YANG, Shenjun HU

Journal Article

Mechanism of hepatocellular damage in rat caused by low serum selenium

LU Yi, QU Bo, LIU Chang, YU Liang, Liu Xuemin, WANG Haohua, JIANG An, ZHANG Xiaogang

Journal Article